dermatologyreview LP2.3
Keratosis pilaris (‘chicken skin’): market review
Which ‘chicken skin’ lotions have the formula to smooth the bumps. The modeller audited body treatments against 34 peer-reviewed clinical papers.
“Most ‘chicken skin’ products are working on the bump you can feel. The evidence says the bump is a keratin plug sealed into a follicle that inflames whenever it is disturbed — Cosmetic scientist model
Independently reviewed by the cosmetic scientist LLM · No connection to, and no payment from, any manufacturer or brand owner · Evidence audit of 118 products · 34 peer-reviewed papers


The hidden-layer model



Independence statement

Test protocol

The key findings
The active ingredients
| Ingredient class | Declared dose / list position | Layer | What the evidence supports | Refs |
|---|---|---|---|---|
| Ammonium lactate / lactic acid | 12% (AmLactin); undeclared, 2nd on the list (Ameliorate); low, 18th–29th (CeraVe); low, 21st (Eucerin) | Two; three | 10% lactic acid cream cut bump count by 66% over 12 weeks in a randomised trial; 12% ammonium lactate is the reference treatment for rough, scaling skin; lactic acid raises the skin’s own ceramide production | 6, 10, 12, 13, 14, 15 |
| Urea | 10%; 10%; 5%; undeclared | Two (≥10%); three (any dose) | Hydrating at any dose; keratolytic from about 10%; improves barrier and water-binding | 16, 17, 18, 27, 34 |
| Salicylic acid and lipo-hydroxy acid | 2%; undeclared | Two | Oil-soluble keratolytic; trialled for these bumps at 5%; capped at 0.5% in a body lotion and 2% in other leave-on products in GB and EU regulation | 6, 20, 30 |
| Glycolic acid | 10% AHA declared (glycolic plus lactic) | One (rinse-off) | Loosens corneocyte bonds in leave-on use; consumer products recommended at ≤10% and pH ≥3.5; increases sun sensitivity; little contact time in a rinse-off | 10, 11, 21, 22, 31 |
| Pumice (physical abrasive) | Undeclared | One | Removes the keratin cap mechanically; no trial in keratosis pilaris; mechanical disturbance is associated with the follicular inflammation the halo represents | 3 |
| Ceramides, cholesterol and phytosphingosine | Undeclared; after the preservative | Three | Physiological lipid mixtures repair the barrier; the skin around the follicle is barrier-deficient | 23, 33 |
| Niacinamide | Undeclared | Three | Increases the skin’s own ceramide synthesis; reduces water loss | 24 |
| Occlusives and emollients (shea butter, mineral oil, dimethicone, sweet almond oil) | Undeclared | Three | Slow water loss; keep the skin around the follicle supple; a plain barrier ointment alone improved the bumps in a comparative trial | 9, 25 |
| Glycerin and natural moisturising factors (sodium lactate, amino acids, sodium PCA, glyceryl glucoside) | Undeclared | Three | Raise hydration; glycerin keeps the lipids between cells fluid; hydration improved in both arms of the keratosis pilaris trial | 6, 19, 26, 27 |
| Soothing agents (bisabolol, allantoin, colloidal oat, feverfew, liquorice, chamomile, green tea) | Undeclared | Three (comfort) | Anti-inflammatory and anti-itch support at cosmetic doses | 28 |
| Fragrance (parfum) | Present | Flag | The commonest cause of contact allergy to a body product; unnecessary on inflamed follicles | 29 |
Final Notes

Reference appendix
References — we go further than most cosmetic reviews and give you the published research the lab study model used on the ingredient combinations, and the published studies behind the top-ranked combination, so you can do your own research.
| No. | Reference | Supports |
|---|---|---|
| 1 | Poskitt L, Wilkinson JD. Natural history of keratosis pilaris. Br J Dermatol 1994; 130(6): 711–713. | |
| 2 | Hwang S, Schwartz RA. Keratosis pilaris: a common follicular hyperkeratosis. Cutis 2008; 82(3): 177–180. | |
| 3 | Wang JF, Orlow SJ. Keratosis pilaris and its subtypes: associations, new molecular and pharmacologic etiologies, and therapeutic options. Am J Clin Dermatol 2018; 19(5): 733–757. | |
| 4 | Gruber R, Sugarman JL, Crumrine D, et al. Sebaceous gland, hair shaft, and epidermal barrier abnormalities in keratosis pilaris with and without filaggrin deficiency. Am J Pathol 2015; 185(4): 1012–1021. | |
| 5 | Thomas M, Khopkar US. Keratosis pilaris revisited: is it more than just a follicular keratosis? Int J Trichology 2012; 4(4): 255–258. | |
| 6 | Kootiratrakarn T, Kampirapap K, Chunhasewee C. Epidermal permeability barrier in the treatment of keratosis pilaris. Dermatol Res Pract 2015; 2015: 205012. | |
| 7 | Maghfour J, Ly S, Haidari W, Taylor SL, Feldman SR. Treatment of keratosis pilaris and its variants: a systematic review. J Dermatolog Treat 2022; 33(3): 1231–1242. | |
| 8 | Novick NL. Practical management of widespread, atypical keratosis pilaris. J Am Acad Dermatol 1984; 11(2 Pt 1): 305–306. | |
| 9 | Breithaupt AD, Alio A, Friedlander SF. A comparative trial comparing the efficacy of tacrolimus 0.1% ointment with Aquaphor ointment for the treatment of keratosis pilaris. Pediatr Dermatol 2011; 28(4): 459–460. | |
| 10 | Van Scott EJ, Yu RJ. Hyperkeratinization, corneocyte cohesion, and alpha hydroxy acids. J Am Acad Dermatol 1984; 11(5 Pt 1): 867–879. | |
| 11 | Berardesca E, Distante F, Vignoli GP, Oresajo C, Green B. Alpha hydroxyacids modulate stratum corneum barrier function. Br J Dermatol 1997; 137(6): 934–938. | |
| 12 | Smith WP. Epidermal and dermal effects of topical lactic acid. J Am Acad Dermatol 1996; 35(3 Pt 1): 388–391. | |
| 13 | Rawlings AV, Davies A, Carlomusto M, et al. Effect of lactic acid isomers on keratinocyte ceramide synthesis, stratum corneum lipid levels and stratum corneum barrier function. Arch Dermatol Res 1996; 288(7): 383–390. | |
| 14 | Rogers RS 3rd, Callen J, Wehr R, Krochmal L. Comparative efficacy of 12% ammonium lactate lotion and 5% lactic acid lotion in the treatment of moderate to severe xerosis. J Am Acad Dermatol 1989; 21(4 Pt 1): 714–716. | |
| 15 | Wehr R, Krochmal L, Bagatell F, Ragsdale W. A controlled two-center study of lactate 12 percent lotion and a petrolatum-based creme in patients with xerosis. Cutis 1986; 37(3): 205–207, 209. | |
| 16 | Celleno L. Topical urea in skincare: a review. Dermatol Ther 2018; 31(6): e12690. | |
| 17 | Pan M, Heinecke G, Bernardo S, Tsui C, Levitt J. Urea: a comprehensive review of the clinical literature. Dermatol Online J 2013; 19(11): 20392. | |
| 18 | Lodén M. Urea-containing moisturizers influence barrier properties of normal skin. Arch Dermatol Res 1996; 288(2): 103–107. | |
| 19 | Weber TM, Kausch M, Rippke F, Schoelermann AM, Filbry AW. Treatment of xerosis with a topical formulation containing glyceryl glucoside, natural moisturizing factors, and ceramide. J Clin Aesthet Dermatol 2012; 5(8): 29–39. | |
| 20 | Arif T. Salicylic acid as a peeling agent: a comprehensive review. Clin Cosmet Investig Dermatol 2015; 8: 455–461. | |
| 21 | Kaidbey K, Sutherland B, Bennett P, et al. Topical glycolic acid enhances photodamage by ultraviolet light. Photodermatol Photoimmunol Photomed 2003; 19(1): 21–27. | |
| 22 | Ditre CM, Griffin TD, Murphy GF, et al. Effects of alpha-hydroxy acids on photoaged skin: a pilot clinical, histologic, and ultrastructural study. J Am Acad Dermatol 1996; 34(2 Pt 1): 187–195. | |
| 23 | Man MQ, Feingold KR, Thornfeldt CR, Elias PM. Optimization of physiological lipid mixtures for barrier repair. J Invest Dermatol 1996; 106(5): 1096–1101. | |
| 24 | Tanno O, Ota Y, Kitamura N, Katsube T, Inoue S. Nicotinamide increases biosynthesis of ceramides as well as other stratum corneum lipids to improve the epidermal permeability barrier. Br J Dermatol 2000; 143(3): 524–531. | |
| 25 | Ghadially R, Halkier-Sorensen L, Elias PM. Effects of petrolatum on stratum corneum structure and function. J Am Acad Dermatol 1992; 26(3 Pt 2): 387–396. | |
| 26 | Fluhr JW, Darlenski R, Surber C. Glycerol and the skin: holistic approach to its origin and functions. Br J Dermatol 2008; 159(1): 23–34. | |
| 27 | Lodén M, Andersson AC, Anderson C, et al. A double-blind study comparing the effect of glycerin and urea on dry, eczematous skin in atopic patients. Acta Derm Venereol 2002; 82(1): 45–47. | |
| 28 | Reynertson KA, Garay M, Nebus J, et al. Anti-inflammatory activities of colloidal oatmeal (Avena sativa) contribute to the effectiveness of oats in treatment of itch associated with dry, irritated skin. J Drugs Dermatol 2015; 14(1): 43–48. | |
| 29 | de Groot AC. Fragrances: contact allergy and other adverse effects. Dermatitis 2020; 31(1): 13–35. | |
| 30 | Commission Regulation (EU) 2019/698 amending Annex III to Regulation (EC) 1223/2009, entry 98 (salicylic acid: maximum 0.5 per cent in body lotions and 2 per cent in other leave-on products); retained in Great Britain under the UK Cosmetics Regulation. | |
| 31 | Cosmetic Ingredient Review Expert Panel. Final report on the safety assessment of glycolic acid, ammonium, calcium, potassium and sodium glycolates, methyl, ethyl, propyl and butyl glycolates, and lactic acid, ammonium, calcium, potassium, sodium and TEA-lactates, methyl, ethyl, isopropyl and butyl lactates, and lauryl, myristyl and cetyl lactates. Int J Toxicol 1998; 17(Suppl 1): 1–241. | |
| 32 | Ibrahim O, Khan M, Bolotin D, et al. Treatment of keratosis pilaris with 810-nm diode laser: a randomized clinical trial. JAMA Dermatol 2015; 151(2): 187–191. | |
| 33 | Elias PM. Stratum corneum defensive functions: an integrated view. J Invest Dermatol 2005; 125(2): 183–200. | |
| 34 | Piquero-Casals J, Morgado-Carrasco D, Granger C, Trullàs C, Jesús-Silva A, Krutmann J. Urea in dermatology: a review of its emollient, moisturizing, keratolytic, skin barrier enhancing and antimicrobial properties. Dermatol Ther (Heidelb) 2021; 11(6): 1905–1915. |
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